Solutions
Bring optogenetic control into your CLD and manufacturing operations
In-house CLD enablement · In-house GMP manufacturing
License the Prolific platform to bring optogenetic control into your own CLD workflows and/or GMP manufacturing operations. Our technology integrates with your existing infrastructure and workflows without disruption - no re-platforming required. You preserve your platform IP and manufacturing know-how while gaining a step-change in performance
Ensure that your cell line is ready for the next generation of molecules, enable new applications like mode of action control, or want to get more out of your current installed base.
Flexible partnering built around your platform
Option 01
Access our light-enabled host cell lines
License Prolific’s light-enabled CHOZN-E™ host within your own CLD workflows — built on industry standard platforms so your team can adopt optogenetic control without disrupting existing processes.
Option 02
Light-enable your proprietary host
Upgrade your proprietary host to be light-controlled, preserving your platform IP and manufacturing know-how while gaining a step-change in performance.
Integration without disruption
1. Rapid Proof of Value (POV)
A focused 6-month study to evaluate optogenetic control on your benchmark molecules and platform — no CapEx required. Generates data to support moving to in-house platform deployment
2. Scoping and feasibility
We collaborate to define a tailored integration plan for your existing platform, workflow, and/or manufacturing infrastructure & operations.
3. Optogenetic cell line development
We either provide light-enabled cell line development services or engineer optogenetic control into your proprietary host - fitted to your existing development and manufacturing workflows.
4. CLD & Manufacturing enablement
Retrofit your existing bioreactors with our add-on illumination hardware — fully qualified and validated to GMP standards. Enables light-controlled expression in your facility without replacing a single bioreactor, delivering more grams per batch with simpler downstream processing
5. Ongoing support
Full technical support, platform upgrades, and hardware servicing, backed by a long-term licensing partnership with Prolific.
Key benefits
Wider Molecule Format Capability
Multispecifics, fusion proteins and other next-gen formats that were previously too difficult to express at viable yields become manufacturable — expanding the programs you can take from discovery to clinic.
Higher Titers on Complex Programs
More than double the productivity of conventional platforms for the most challenging molecules. Better process economics from the start, lower cost of goods, more programs viable at commercial scale.
Unprecedented CQA control
Light-controlled CLD and bioprocess reduces variability across projects and from CLD to scale-up.
Faster IND
Compressed CLD timelines. Programs that previously stalled in development due to manufacturability issues move forward with a complete, CDMO-ready data package.
Seamless CDMO Transfer
A complete tech transfer package: process parameters, characterisation data, scale-up models, and on-site Prolific support at your CDMO.
CDMO-Agnostic Flexibility
We work with your preferred CDMO or manufacturing facility. No lock-in. The Prolific platform transfers to any GMP facility giving you full control over selection of manufacturing partner.